Breakthrough in Cancer Treatment

[drunkenshoe]

Anyone's seen this? Well, this kind of news are on and off about a few times a year, but it looks good. The medicine is in phase one.

https://pubmed.ncbi.nlm.nih.gov/37531956/

Small molecule targeting of transcription-replication conflict for selective chemotherapy (July 2023)

Abstract

Targeting transcription replication conflicts, a major source of endogenous DNA double-stranded breaks and genomic instability could have important anticancer therapeutic implications. Proliferating cell nuclear antigen (PCNA) is critical to DNA replication and repair processes. Through a rational drug design approach, we identified a small molecule PCNA inhibitor, AOH1996, which selectively kills cancer cells. AOH1996 enhances the interaction between PCNA and the largest subunit of RNA polymerase II, RPB1, and dissociates PCNA from actively transcribed chromatin regions, while inducing DNA double-stranded breaks in a transcription-dependent manner. Attenuation of RPB1 interaction with PCNA, by a point mutation in RPB1's PCNA-binding region, confers resistance to AOH1996. Orally administrable and metabolically stable, AOH1996 suppresses tumor growth as a monotherapy or as a combination treatment but causes no discernable side effects. Inhibitors of transcription replication conflict resolution may provide a new and unique therapeutic avenue for exploiting this cancer-selective vulnerability.

Protein Destroys 'Hard to Treat' Cancers, Could Become 'One Size Fits All' Pill (Jun 2023)

https://www.goodnewsnetwork.org/university-of-texas-cancer-breakthrough-erx-41/

[Mike Cl]

Anyone's seen this? Well, this kind of news are on and off about a few times a year, but it looks good. The medicine is in phase one.

https://pubmed.ncbi.nlm.nih.gov/37531956/

Small molecule targeting of transcription-replication conflict for selective chemotherapy (July 2023)

Protein Destroys 'Hard to Treat' Cancers, Could Become 'One Size Fits All' Pill (Jun 2023)

https://www.goodnewsnetwork.org/university-of-texas-cancer-breakthrough-erx-41/

Have to ask my Dr's about this;  my MDS is a form of cancer that is not curable; but proper treatment is essential.  A type of chemo is one treatment option for it; could this new protein chemo have a positive impact on my disease?  Fun to think about it!

[Dark Lightning]

I like seeing this kind of medical advancement. If my marrow gets completely stupid and I develop multiple myeloma (1 in 4 chance of it, but likely many years away), there is a decent chemo being developed for it. Perhaps the current issue could be fixed. That would be nice.

[Unbeliever]

When I was young I was really stupid and figured that by the time I got cancer there would be a cure for it, so I smoked.
Maybe I wasn't wrong after all...

🤔

[Gawdzilla Sama]

My luck I'll be allergic to whatever it is.