News:

Welcome to our site!

Main Menu

Oldest Known Human DNA Recovered

Started by stromboli, December 04, 2013, 08:23:13 PM

Previous topic - Next topic

stromboli

http://www.realclearscience.com/blog/20 ... lyzed.html

QuoteThe most famous site at Atapuerca, Sima de los Huesos -- "The Pit of Bones" -- is precisely that. Located at the bottom of a 43-foot chimney in the winding cave system of Cueva Mayor, it contains approximately 5,500 ancient human bones dated at over 350,000 years old! Now, drawing upon this piled wealth of history, Matthias Meyer, a lead researcher at the Max Planck Institute for Evolutionary Anthropology, and a team of colleagues have recovered and analyzed the earliest known human DNA.

DNA, as you may very well know, is the molecular instruction manual for how to build life, and the DNA at Sima de los Huesos is thought to belong to Homo heidelbergensis, a group of extinct humans roughly comparable in height and looks to Neanderthals. Drilling into a femur present at the site, the team collected about two grams worth of bone, then isolated DNA using a recently discovered method that employs silica to make the process more efficient. The team focused on the DNA contained within mitochondria -- the powerhouses of cells -- which holds vastly fewer genes than does nuclear DNA, which is contained within cells' nuclei. Because mitochondrial DNA is passed down exclusively from mothers, there are usually no changes from parent to offspring. This makes it a powerful tool for tracking ancestry, which is precisely what the researchers used it for.

After sequencing 98% of the mitochondrial DNA genome, Meyer and his colleagues estimated the specimen's age using the length of the DNA branch as a proxy. The femur clocked in at around 400,000 years old, placing its former owner in the Middle Pleistocene and making the DNA by far and away oldest human DNA ever collected. The previous record belonged to 100,000-year-old Neanderthal DNA.

The team then attempted to determine the specimen's position in the ancient human family tree and were surprised to find that the owner did not share a common ancestor with Neanderthals, but instead with Denisovans, a mysterious subspecies of human discovered in 2008 that last shared an ancestor with Neanderthals and Homo sapiens about one million years ago. Indeed, the more scientists discover about our prehistoric ancestors, the further they seem to fall down Alice's Rabbit Hole. Things just get curiouser and curiouser.

Meyer presented three possibilities that could account for the team's unexpected findings.*

"First, the Sima de los Huesos hominins may be closely related to the ancestors of Denisovans."

"Second, it is possible that the Sima de los Huesos hominins represent a group distinct from both Neanderthals and Denisovans that later perhaps contributed the mtDNA to Denisovans."

"Third, the Sima de los Huesos hominins may be related to the population ancestral to both Neanderthals and Denisovans."

Hey Jackdaw if you are still around, THIS is science. Just thought you'd like to know.

Atheon

The pit is in Spain, just so people know.

This is cool! But I would like to see more sampling and analysis done.
"Religion is regarded by the common people as true, by the wise as false, and by the rulers as useful." - Seneca

mykcob4

Quote from: "stromboli"http://www.realclearscience.com/blog/2013/12/oldest_known_early_human_dna_recovered_analyzed.html

QuoteThe most famous site at Atapuerca, Sima de los Huesos -- "The Pit of Bones" -- is precisely that. Located at the bottom of a 43-foot chimney in the winding cave system of Cueva Mayor, it contains approximately 5,500 ancient human bones dated at over 350,000 years old! Now, drawing upon this piled wealth of history, Matthias Meyer, a lead researcher at the Max Planck Institute for Evolutionary Anthropology, and a team of colleagues have recovered and analyzed the earliest known human DNA.

DNA, as you may very well know, is the molecular instruction manual for how to build life, and the DNA at Sima de los Huesos is thought to belong to Homo heidelbergensis, a group of extinct humans roughly comparable in height and looks to Neanderthals. Drilling into a femur present at the site, the team collected about two grams worth of bone, then isolated DNA using a recently discovered method that employs silica to make the process more efficient. The team focused on the DNA contained within mitochondria -- the powerhouses of cells -- which holds vastly fewer genes than does nuclear DNA, which is contained within cells' nuclei. Because mitochondrial DNA is passed down exclusively from mothers, there are usually no changes from parent to offspring. This makes it a powerful tool for tracking ancestry, which is precisely what the researchers used it for.

After sequencing 98% of the mitochondrial DNA genome, Meyer and his colleagues estimated the specimen's age using the length of the DNA branch as a proxy. The femur clocked in at around 400,000 years old, placing its former owner in the Middle Pleistocene and making the DNA by far and away oldest human DNA ever collected. The previous record belonged to 100,000-year-old Neanderthal DNA.

The team then attempted to determine the specimen's position in the ancient human family tree and were surprised to find that the owner did not share a common ancestor with Neanderthals, but instead with Denisovans, a mysterious subspecies of human discovered in 2008 that last shared an ancestor with Neanderthals and Homo sapiens about one million years ago. Indeed, the more scientists discover about our prehistoric ancestors, the further they seem to fall down Alice's Rabbit Hole. Things just get curiouser and curiouser.

Meyer presented three possibilities that could account for the team's unexpected findings.*

"First, the Sima de los Huesos hominins may be closely related to the ancestors of Denisovans."

"Second, it is possible that the Sima de los Huesos hominins represent a group distinct from both Neanderthals and Denisovans that later perhaps contributed the mtDNA to Denisovans."

"Third, the Sima de los Huesos hominins may be related to the population ancestral to both Neanderthals and Denisovans."

Hey Jackdaw if you are still around, THIS is science. Just thought you'd like to know.
Now how in the world did those people get MY DNA?!

leo

I don't think this jack fucker care about the truth.
Religion is Bullshit  . The winner of the last person to post wins thread .

stromboli

I find this stuff very cool because it expands our knowledge about human evolution with evidence that is very hard to refute. DNA sequencing, especially Mitochondria, is accurate and as widely accepted as any proof can be.

This is a dagger in the side of Creationism, and I love it.