Something that gives me comfort, that gives me that awe and inspiration you often see with religious types have about their make believe gods, for me its looking up into the night sky and thinking about the vastness of space, all the galaxies and stars and voids out there. When you think, we are the only species on the planet that has not only thought about these things, but we've observed them, from afar, and sent up our technology into space to observe it.
Now on that, as religious sorts have a central theme of immortality, just about all religions believe we have an immortal soul that when we die either goes and lives somewhere good or bad for eternity, or gets reincarnated into something new. The irony of this however is when you really consider the universe in its entirety, just like us and out lifespans, the universe itself is of a lifespan.
The idea of living forever just seems all the more daft when you consider in the far, far distant future, there will be nothing there, just a void where the universe once was, and nothing to remember it.
So just on the fact of knowing everything will just simply not be anymore, like when our sun explodes and wipes out our planet, so when all supermassive black holes consume all atoms in the universe, its best to just live in there here and now and enjoy the ride.